Evaluation of Pre-Malignant and Malignant Lesions in Cervico Vaginal (Pap ) Smears by Nuclear Morphometry
Published: November 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.5221
Divya Rani M.N, Aparna Narasimha, Harendra Kumar ML, Sheela SR
1. Resident, Department of Pathology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.
2. Professor, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
3. Professor and HOD, Department of Pathology, Sri Devraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
4. Professor, Department of Obstretics and Gynaecology, Sri Devarj Urs Academy of Higher Education and Researcg, Kolar, Karnataka, India.
Correspondence
Dr. Aparna Narasimha,
No. 22, “Moyenvilla”, Moyenville Road, Langford Town, Bangalore - 25, India.
Phone : 9632140850, E-mai : Sonrichie14@gmail.com
Background: Cervical cancer is the second most common cancer occurring among women worldwide, with almost half a million new cases each year. Normal cells gradually transform to form cancer cells through several stages. So, the changes occurring during the transformational stages need to be assessed.
Aim: Our aim was to study various nuclear parameters useful in evaluating pre-malignant and malignant cervico-vaginal pap smears. Materials and Methods: Bethesda System was used to categorize cervical pap smears into premalignant and malignant lesions. Nuclear parameters were calculated using J 1.44C morphometric software. Several nuclear size parameters were analysed.
Results: The nuclear area, perimeter, diameter were found to be statistically significant (p<0.05) parameters in differentiating premalignant from malignant cervical smears.
Conclusion: Nuclear morphometry was thus a useful objective tool in differentiating premalignant from malignant cervical smears.
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